Edington Sean

Sean Edington

Assistant Professor
Assistant Professor
Assistant Professor
Phone: (603) 862-0015
Office: UNH COLSA Molecular Cellular & Biomedical, Rudman Hall, Durham, NH 03824
Websites:
Pronouns: He/him/his

In my lab, we use time-resolved laser spectroscopy and mass spectrometry to understand how ions bind to molecules and proteins. We are applying this molecular-level knowledge to understand how mutations to ion binding sites in signaling proteins can cause a wide range of diseases including cancer, Alzheimer's, and heart disease. This is an exciting area because many different proteins use ion binding sites that are similar to one another; if we can build a model of how changes to one binding site cause disease, we will likely be able to use that model to understand how ion binding sites contribute to malfunction in many different diseases.

Courses Taught

  • BMCB 795W: Invest in Molecular & Cell Bio
  • CHEM 684: Physical Chemistry II
  • INCO 590: Student Research Experience
  • INCO 790: Advanced Research Experience
  • MCBS 901: Intro to Research in Life Sci

Education

  • Ph.D., Physical Chemistry, Princeton University
  • Post-doctor, University of Texas at Austin
  • Post-doctor, Physical Chemistry, Yale University
  • B.S., Chemistry, University of Virginia

Research Interests

  • Physical Chemistry
  • Spectroscopy
  • Biophysics
  • Signal Transduction (Sensory/Cellular)
  • Lasers and Masers
  • Ultrafast Chemistry
  • Biochemistry, Proteins
  • Analytical Chemistry

Selected Publications

  • Maitra, A., Lake, W. R., Mohamed, A., Edington, S. C., Das, P., Thompson, B. C., . . . Dawlaty, J. M. (2024). Measuring the Electric Fields of Ions Captured in Crown Ethers.. J Phys Chem Lett, 15(29), 7458-7465. doi:10.1021/acs.jpclett.4c01303

  • Harville, P. A., Edington, S. C., Moss, O. C., Huang, M., McCoy, A. B., & Johnson, M. A. (2024). High-resolution vibrational predissociation spectroscopy of I
    −
     · H
    2
    O by single-mode CW infrared excitation in a 3D cryogenic ion trap. Molecular Physics, 122(1-2). doi:10.1080/00268976.2023.2174784

  • Khuu, T., Rana, A., Edington, S. C., Yang, N., McCoy, A. B., & Johnson, M. A. (2023). Observation of Slow Eigen-Zundel Interconversion in H+(H2O)6 Clusters upon Isomer-Selective Vibrational Excitation and Buffer Gas Cooling in a Cryogenic Ion Trap.. J Am Soc Mass Spectrom, 34(4), 737-744. doi:10.1021/jasms.3c00007

  • Mohamed, A., Edington, S. C., Secor, M., Breton, J. R., Hammes-Schiffer, S., & Johnson, M. A. (2023). Spectroscopic Characterization of the Divalent Metal Docking Motif to Isolated Cyanobenzoate: Direct Observation of Tridentate Binding to ortho-Cyanobenzoate and Implications for the CN Response.. J Phys Chem A, 127(6), 1413-1421. doi:10.1021/acs.jpca.2c07658

  • Stropoli, S. J., Khuu, T., Messinger, J. P., Karimova, N. V., Boyer, M. A., Zakai, I., . . . Johnson, M. A. (2022). Preparation and Characterization of the Halogen-Bonding Motif in the Isolated Cl-·IOH Complex with Cryogenic Ion Vibrational Spectroscopy.. J Phys Chem Lett, 13(12), 2750-2756. doi:10.1021/acs.jpclett.2c00218

  • Menges, F. S., Perez, E. H., Edington, S. C., Duong, C. H., Yang, N., & Johnson, M. A. (2019). Integration of High-Resolution Mass Spectrometry with Cryogenic Ion Vibrational Spectroscopy.. J Am Soc Mass Spectrom, 30(9), 1551-1557. doi:10.1007/s13361-019-02238-y

  • Edington, S. C., Halling, D. B., Bennett, S. M., Middendorf, T. R., Aldrich, R. W., & Baiz, C. R. (2019). Non-Additive Effects of Binding Site Mutations in Calmodulin.. Biochemistry, 58(24), 2730-2739. doi:10.1021/acs.biochem.9b00096

  • Edington, S. C., & Baiz, C. R. (2018). Vibrational Relaxation in EDTA Is Ion-Dependent.. J Phys Chem A, 122(32), 6585-6592. doi:10.1021/acs.jpca.8b06075

  • Edington, S. C., Gonzalez, A., Middendorf, T. R., Halling, D. B., Aldrich, R. W., & Baiz, C. R. (2018). Coordination to lanthanide ions distorts binding site conformation in calmodulin.. Proc Natl Acad Sci U S A, 115(14), E3126-E3134. doi:10.1073/pnas.1722042115

  • Edington, S. C., Flanagan, J. C., & Baiz, C. R. (2016). An Empirical IR Frequency Map for Ester C═O Stretching Vibrations.. J Phys Chem A, 120(22), 3888-3896. doi:10.1021/acs.jpca.6b02887

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  • Most Cited Publications