Sarah Walker

ASSISTANT PROFESSOR
Phone: (603) 862-3782
Office: Molecular, Cellular, & Biomedical Sciences, Rudman Hall Rm 185, Durham, NH 03824
Sarah Walker

My research focuses on understanding the roles of STATs and related transcription factors in breast and ovarian cancer and we use that knowledge to identify drugs to target the pathways associated with these transcription factors. In my lab, we use a 3D culturing system to mimic advanced stages of cancer. Moreover, we use a combination of wet lab experiments and bioinformatics to identify possible drugs for the treatment of breast and ovarian cancer.

Education

  • Ph.D., Cell and Developmental Biology, Harvard University
  • B.S., Biology, Rensselaer Polytechnic Institute
  • B.S., Bioinformatics and Molecular Biology, Rensselaer Polytechnic Institute

Research Interests

  • Breast Cancer
  • Cancer Biology
  • Cell Lines
  • Cellular Biology
  • Drug Discovery
  • Drug Resistance
  • Molecular Biology
  • Ovarian Cancer

Courses Taught

  • 401: Persp Biochem/Mole&Cell Bio
  • 590: Student Research Experience
  • 605: Principles of Cell Biology
  • 790: Advanced Research Experience
  • 799H: Honors Senior Thesis
  • 825/725: Cell Pheno & Tissue Eng Lab
  • 999: Doctoral Thesis
  • BCHM/BENG/BMS 825/725: Cell Pheno & Tissue Eng Lab
  • BCHM/BMS 825/725: Cell Pheno & Tissue Eng Lab
  • BENG/BMS 620: Tissue Engineering
  • BMCB 605: Principles of Cell Biology
  • BMCB 790: Undergrad Teaching Experience
  • BMCB 799H: Honors Senior Thesis
  • BMS 790: Undergrad Teaching Experience
  • BMS 795W: Investigations Biomedical Sci
  • BMS 799H: Senior Honors Thesis
  • INCO 590: Rsrch Exp/MCBS
  • MCBS 999: Doctoral Thesis

Selected Publications

Heppler, L. N., Attarha, S., Persaud, R., Brown, J. I., Wang, P., Petrova, B., . . . Frank, D. A. (2022). The antimicrobial drug pyrimethamine inhibits STAT3 transcriptional activity by targeting the enzyme dihydrofolate reductase. Journal of Biological Chemistry, 298(2), 101531. doi:10.1016/j.jbc.2021.101531

Brown, J. R., Walker, S. R., Heppler, L. N., Tyekucheva, S., Nelson, E. A., Klitgaard, J., . . . Frank, D. A. (2021). Targeting constitutively active
<scp>STAT3</scp>
in chronic lymphocytic leukemia: A clinical trial of the
<scp>STAT3</scp>
inhibitor pyrimethamine with pharmacodynamic analyses. American Journal of Hematology, 96(4). doi:10.1002/ajh.26084

Matissek, S. J., Han, W., Karbalivand, M., Sayed, M., Reilly, B. M., Mallat, S., . . . Elsawa, S. F. (2021). Epigenetic targeting of Waldenstrom macroglobulinemia cells with BET inhibitors synergizes with BCL2 or histone deacetylase inhibition. EPIGENOMICS, 13(02), 129-144. doi:10.2217/epi-2020-0189

Walker, D. F., Lacroix, S. J., Makar, Y., & Walker, S. R. (2020). Abstract 6077: The role of STAT3 and Snai2 in ovarian cancer metastasis. In Cancer Research Vol. 80 (pp. 6077). American Association for Cancer Research (AACR). doi:10.1158/1538-7445.am2020-6077

Nguyen, D. N. H., Walker, D. F., Frank, D. A., & Walker, S. R. (2020). Abstract 2730: BCL6 promotes ovarian cancer metastasis. In Cancer Research Vol. 80 (pp. 2730). American Association for Cancer Research (AACR). doi:10.1158/1538-7445.am2020-2730

Lee, R. E. C., Walker, S. R., Savery, K., Frank, D. A., & Gaudet, S. (2014). Fold change of nuclear NF-κB determines TNF-induced transcription in single cells.. Mol Cell, 53(6), 867-879. doi:10.1016/j.molcel.2014.01.026

Chmielecki, J., Crago, A. M., Rosenberg, M., O'Connor, R., Walker, S. R., Ambrogio, L., . . . Meyerson, M. (2013). Whole-exome sequencing identifies a recurrent NAB2-STAT6 fusion in solitary fibrous tumors.. Nat Genet, 45(2), 131-132. doi:10.1038/ng.2522

Marotta, L. L. C., Almendro, V., Marusyk, A., Shipitsin, M., Schemme, J., Walker, S. R., . . . Polyak, K. (2011). The JAK2/STAT3 signaling pathway is required for growth of CD44⁺CD24⁻ stem cell-like breast cancer cells in human tumors.. J Clin Invest, 121(7), 2723-2735. doi:10.1172/JCI44745

Nelson, E. A., Walker, S. R., Weisberg, E., Bar-Natan, M., Barrett, R., Gashin, L. B., . . . Frank, D. A. (2011). The STAT5 inhibitor pimozide decreases survival of chronic myelogenous leukemia cells resistant to kinase inhibitors.. Blood, 117(12), 3421-3429. doi:10.1182/blood-2009-11-255232

Keese, C. R., Wegener, J., Walker, S. R., & Giaever, I. (2004). Electrical wound-healing assay for cells in vitro.. Proc Natl Acad Sci U S A, 101(6), 1554-1559. doi:10.1073/pnas.0307588100

Most Cited Publications