Sarah Walker

ASSISTANT PROFESSOR
Phone: (603) 862-3782
Office: Molecular, Cellular, & Biomedical Sciences, Rudman Hall Rm 185, Durham, NH 03824
Sarah Walker

My research focuses on understanding the roles of STATs and related transcription factors in breast and ovarian cancer and we use that knowledge to identify drugs to target the pathways associated with these transcription factors. In my lab, we use a 3D culturing system to mimic advanced stages of cancer. Moreover, we use a combination of wet lab experiments and bioinformatics to identify possible drugs for the treatment of breast and ovarian cancer.

Education

  • Ph.D., Cell and Developmental Biology, Harvard University
  • B.S., Bioinformatics and Molecular Biology, Rensselaer Polytechnic Institute
  • B.S., Biology, Rensselaer Polytechnic Institute

Research Interests

  • Breast Cancer
  • Cancer Biology
  • Cell Lines
  • Cellular Biology
  • Drug Discovery
  • Drug Resistance
  • Molecular Biology
  • Ovarian Cancer

Courses Taught

  • BENG/BMS 620: Tissue Engineering
  • BMCB 605: Principles of Cell Biology
  • BMCB 790: Undergrad Teaching Experience
  • BMCB 799H: Honors Senior Thesis
  • BMS 795W: Investigations Biomedical Sci
  • BMS 799H: Senior Honors Thesis

Selected Publications

Niu, J., Sun, Y., Chen, B., Zheng, B., Jarugumilli, G. K., Walker, S. R., . . . Wu, X. (2019). Fatty acids and cancer-amplified ZDHHC19 promote STAT3 activation through S-palmitoylation. Nature, 573(7772), 139-143. doi:10.1038/s41586-019-1511-x

Chen, C. -H., Bhasin, S., Khanna, P., Joshi, M., Joslin, P. M. N., Saxena, R., . . . Bhatt, R. S. (2019). Study of Cathepsin B inhibition in VEGFR TKI treated human renal cell carcinoma xenografts. Oncogenesis, 8(3). doi:10.1038/s41389-019-0121-7

Liu, S., Marneth, A. E., Alexe, G., Walker, S. R., Gandler, H. I., Ye, D. Q., . . . Frank, D. A. (2018). The kinases IKBKE and TBK1 regulate MYC-dependent survival pathways through YB-1 in AML and are targets for therapy. Blood Advances, 2(23), 3428-3442. doi:10.1182/bloodadvances.2018016733

Brown, J. R., Walker, S. R., Heppler, L. N., Tyekucheva, S., Nelson, E., Klitgaard, J. L., . . . Frank, D. A. (2018). A Clinical Trial of the STAT3 Inhibitor Pyrimethamine in Chronic Lymphocytic Leukemia. Blood, 132(Supplement 1), 1855. doi:10.1182/blood-2018-99-118921

Karakasheva, T. A., Lin, E. W., Tang, Q., Qiao, E., Waldron, T. J., Soni, M., . . . Rustgi, A. K. (2018). IL-6 Mediates Cross-Talk between Tumor Cells and Activated Fibroblasts in the Tumor Microenvironment. Cancer Research, 78(17), 4957-4970. doi:10.1158/0008-5472.can-17-2268

Lee, R. E. C., Walker, S. R., Savery, K., Frank, D. A., & Gaudet, S. (2014). Fold Change of Nuclear NF-κB Determines TNF-Induced Transcription in Single Cells. Molecular Cell, 53(6), 867-879. doi:10.1016/j.molcel.2014.01.026

Chmielecki, J., Crago, A. M., Rosenberg, M., O'Connor, R., Walker, S. R., Ambrogio, L., . . . Meyerson, M. (2013). Whole-exome sequencing identifies a recurrent NAB2-STAT6 fusion in solitary fibrous tumors. Nature Genetics, 45(2), 131-132. doi:10.1038/ng.2522

Marotta, L. L. C., Almendro, V., Marusyk, A., Shipitsin, M., Schemme, J., Walker, S. R., . . . Polyak, K. (2011). The JAK2/STAT3 signaling pathway is required for growth of CD44+CD24– stem cell–like breast cancer cells in human tumors. Journal of Clinical Investigation, 121(7), 2723-2735. doi:10.1172/jci44745

Nelson, E. A., Walker, S. R., Weisberg, E., Bar-Natan, M., Barrett, R., Gashin, L. B., . . . Frank, D. A. (2011). The STAT5 inhibitor pimozide decreases survival of chronic myelogenous leukemia cells resistant to kinase inhibitors. Blood, 117(12), 3421-3429. doi:10.1182/blood-2009-11-255232

Keese, C. R., Wegener, J., Walker, S. R., & Giaever, I. (2004). Electrical wound-healing assay for cells in vitro. Proceedings of the National Academy of Sciences, 101(6), 1554-1559. doi:10.1073/pnas.0307588100

Most Cited Publications