
Sarah Walker
Courses Taught
- BCHM 825: Cell Pheno & Tissue Eng Lab
- BCHM/BENG/BMS 825/725: Cell Pheno & Tissue Eng Lab
- BCHM/BENG/BMS 825/725/825/725: Cell Pheno & Tissue Eng Lab
- BCHM/BMS 825/725: Cell Pheno & Tissue Eng Lab
- BCHM/CHBE 825/725: Cell Pheno & Tissue Eng Lab
- BMCB 401: Persp Biochem/Mole&Cell Bio
- BMCB 605: Principles of Cell Biology
- BMCB 795W: Invest in Molecular & Cell Bio
- BMCB 799H: Honors Senior Thesis
- BMS 725: Cell Pheno & Tissue Eng Lab
- BMS 790: Undergrad Teaching Experience
- BMS 799H: Senior Honors Thesis
- BMS/CHBE 725: Cell Pheno & Tissue Eng Lab
- GEN 799H: Honors Senior Thesis
- INCO 590: Student Research Experience
- INCO 790: Advanced Research Experience
- MCBS 997: Seminar
- MCBS 999: Doctoral Research
Education
- Ph.D., Cell and Developmental Biology, Harvard University
- B.S., Biology, Rensselaer Polytechnic Institute
- B.S., Bioinformatics and Molecular Biology, Rensselaer Polytechnic Institute
Research Interests
- Breast Cancer
- Cancer Biology
- Cell Lines
- Cellular Biology
- Drug Discovery
- Drug Resistance
- Molecular Biology
- Ovarian Cancer
Selected Publications
Stevens, L. E., Peluffo, G., Qiu, X., Temko, D., Fassl, A., Li, Z., . . . Polyak, K. (2023). JAK-STAT Signaling in Inflammatory Breast Cancer Enables Chemotherapy-Resistant Cell States.. Cancer Res, 83(2), 264-284. doi:10.1158/0008-5472.CAN-22-0423
Heppler, L. N., Attarha, S., Persaud, R., Brown, J. I., Wang, P., Petrova, B., . . . Frank, D. A. (2022). The antimicrobial drug pyrimethamine inhibits STAT3 transcriptional activity by targeting the enzyme dihydrofolate reductase. Journal of Biological Chemistry, 298(2), 101531. doi:10.1016/j.jbc.2021.101531
Brown, J. R., Walker, S. R., Heppler, L. N., Tyekucheva, S., Nelson, E. A., Klitgaard, J., . . . Frank, D. A. (2021). Targeting constitutively active STAT3 in chronic lymphocytic leukemia: A clinical trial of the STAT3 inhibitor pyrimethamine with pharmacodynamic analyses. American Journal of Hematology, 96(4). doi:10.1002/ajh.26084
Matissek, S. J., Han, W., Karbalivand, M., Sayed, M., Reilly, B. M., Mallat, S., . . . Elsawa, S. F. (2021). Epigenetic targeting of Waldenstrom macroglobulinemia cells with BET inhibitors synergizes with BCL2 or histone deacetylase inhibition. EPIGENOMICS, 13(02), 129-144. doi:10.2217/epi-2020-0189
Nguyen, D. N. H., Walker, D. F., Frank, D. A., & Walker, S. R. (2020). Abstract 2730: BCL6 promotes ovarian cancer metastasis. In Cancer Research Vol. 80 (pp. 2730). American Association for Cancer Research (AACR). doi:10.1158/1538-7445.am2020-2730
Izar, B., Tirosh, I., Stover, E. H., Wakiro, I., Cuoco, M. S., Alter, I., . . . Regev, A. (2020). A single-cell landscape of high-grade serous ovarian cancer.. Nat Med, 26(8), 1271-1279. doi:10.1038/s41591-020-0926-0
Chmielecki, J., Crago, A. M., Rosenberg, M., O'Connor, R., Walker, S. R., Ambrogio, L., . . . Meyerson, M. (2013). Whole-exome sequencing identifies a recurrent NAB2-STAT6 fusion in solitary fibrous tumors.. Nat Genet, 45(2), 131-132. doi:10.1038/ng.2522
Marotta, L. L. C., Almendro, V., Marusyk, A., Shipitsin, M., Schemme, J., Walker, S. R., . . . Polyak, K. (2011). The JAK2/STAT3 signaling pathway is required for growth of CD44⁺CD24⁻ stem cell-like breast cancer cells in human tumors.. J Clin Invest, 121(7), 2723-2735. doi:10.1172/JCI44745
Nelson, E. A., Walker, S. R., Weisberg, E., Bar-Natan, M., Barrett, R., Gashin, L. B., . . . Frank, D. A. (2011). The STAT5 inhibitor pimozide decreases survival of chronic myelogenous leukemia cells resistant to kinase inhibitors.. Blood, 117(12), 3421-3429. doi:10.1182/blood-2009-11-255232
Keese, C. R., Wegener, J., Walker, S. R., & Giaever, I. (2004). Electrical wound-healing assay for cells in vitro.. Proc Natl Acad Sci U S A, 101(6), 1554-1559. doi:10.1073/pnas.0307588100