Paul Tsang

PROFESSOR
Phone: (603) 862-3479
Office: Hamel Center for Undergraduate Research, Conant Hall Room 118H, Durham, NH 03824
Tsang

The major focus in my laboratory is to study the role of matrix metalloproteinases (MMPs) and their inhibitors (TIMPs) in regulating corpus luteum architecture and function. By utilizing northern and western blotting, zymography, in situ hybridization, immunohistochemistry, and cell culture techniques, we have been able to identify the presence of MMPs (gelatinases, membrane-type 1 and TIMPs (e.g., TIMP-1, TIMP-2, TIMP-3) in the cow corpus luteum over the estrous cycle. We have also shown that TIMP-1 and TIMP-2 proteins decrease dramatically in sheep corpus luteum following a one-hour infusion of prostaglandin F2a (PGF2a).

Recently, a second focus in my laboratory is to study age and growth, reproductive cyclicity and genetics of two skate species found in the Gulf of Maine. This information is vital to the development of a fisheries management plan for these two over-fished elasmobranchs.

Utilizing the technique of ultrasonography, we also participate in a regional project examining the regulation of follicle development in cattle.

Faculty Award Winner

Award Type:  COLSA Outstanding Advisor Award
Year:  2013

Education

  • Ph.D., Biology, Boston University
  • B.A., Anatomy and Physiology, Cornell University

Courses Taught

  • BCHM 802: Endocrinology
  • BMCB 605: Eukaryotic Cell & DevlpBio\Hon
  • INCO 590: Student Research Experience
  • INCO 790: Advanced Research Experience

Selected Publications

Prohaska, B. K., Tsang, P. C. W., Driggers, W. B., Hoffmayer, E. R., Wheeler, C. R., & Sulikowski, J. A. (2018). Effects of delayed phlebotomy on plasma steroid hormone concentrations in two elasmobranch species. Journal of Applied Ichthyology, 34(4), 861-866. doi:10.1111/jai.13700

Foradori, M. J., Chen, Q., Fernandez, C. A., Harper, J., Li, X., Tsang, P. C. W., . . . Moses, M. A. (2014). Matrilin-1 Is an Inhibitor of Neovascularization. Journal of Biological Chemistry, 289(20), 14301-14309. doi:10.1074/jbc.m113.529982

Prohaska, B. K., Tsang, P. C. W., Driggers, W. B., Hoffmayer, E. R., Wheeler, C. R., Brown, A. C., & Sulikowski, J. A. (2013). Assessing reproductive status in elasmobranch fishes using steroid hormones extracted from skeletal muscle tissue. Conservation Physiology, 1(1), cot028. doi:10.1093/conphys/cot028

Bubley, W. J., Sulikowski, J. A., Koester, D. M., & Tsang, P. C. W. (2013). Using a multi-parameter approach to reassess maturity of spiny dogfish, Squalus acanthias, following increased fishing pressure in the Western North Atlantic. Fisheries Research, 147, 202-212. doi:10.1016/j.fishres.2013.06.004

Williams, L. J., Campbell, M. D., Tsang, P. C. W., & Sulikowski, J. A. (2013). Using estradiol and progesterone concentrations to assess individual variability in the reproductive cyclicity of captive female little skates, Leucoraja erinacea, from the western Gulf of Maine. Fish Physiology and Biochemistry, 39(5), 1089-1099. doi:10.1007/s10695-012-9766-2

Townson, D. H., Tsang, P. C. W., Butler, W. R., Frajblat, M., Griel, L. C., Johnson, C. J., . . . Pate, J. L. (2002). Relationship of fertility to ovarian follicular waves before breeding in dairy cows. Journal of Animal Science, 80(4), 1053-1058. doi:10.2527/2002.8041053x

Ahmad, N., Beam, S. W., Butler, W. R., Deaver, D. R., Duby, R. T., Elder, D. R., . . . Inskeep, E. K. (1996). Relationship of fertility to patterns of ovarian follicular development and associated hormonal profiles in dairy cows and heifers. JOURNAL OF ANIMAL SCIENCE, 74(8), 1943-1952. Retrieved from http://gateway.webofknowledge.com/

Relationship of fertility to patterns of ovarian follicular development and associated hormonal profiles in dairy cows and heifers (1996). Journal of Animal Science, 74(8), 1943-1952. doi:10.2527/1996.7481943x

Hinshelwood, M. M., Corbin, C. J., Tsang, P. C., & Simpson, E. R. (1993). Isolation and characterization of a complementary deoxyribonucleic acid insert encoding bovine aromatase cytochrome P450.. Endocrinology, 133(5), 1971-1977. doi:10.1210/endo.133.5.8404644

CALLARD, I. P., FILETI, L. A., PEREZ, L. E., SORBERA, L. A., GIANNOUKOS, G., KLOSTERMAN, L. L., . . . MCCRACKEN, J. A. (1992). Role of the Corpus Luteum and Progesterone in the Evolution of Vertebrate Viviparity. American Zoologist, 32(2), 264-275. doi:10.1093/icb/32.2.264

Most Cited Publications