Paul Tsang

Phone: (603) 862-3479
Office: Hamel Center for Undergraduate Research, Conant Hall Room 118H, Durham, NH 03824

The major focus in my laboratory is to study the role of matrix metalloproteinases (MMPs) and their inhibitors (TIMPs) in regulating corpus luteum architecture and function. By utilizing northern and western blotting, zymography, in situ hybridization, immunohistochemistry, and cell culture techniques, we have been able to identify the presence of MMPs (gelatinases, membrane-type 1 and TIMPs (e.g., TIMP-1, TIMP-2, TIMP-3) in the cow corpus luteum over the estrous cycle. We have also shown that TIMP-1 and TIMP-2 proteins decrease dramatically in sheep corpus luteum following a one-hour infusion of prostaglandin F2a (PGF2a).

Recently, a second focus in my laboratory is to study age and growth, reproductive cyclicity and genetics of two skate species found in the Gulf of Maine. This information is vital to the development of a fisheries management plan for these two over-fished elasmobranchs.

Utilizing the technique of ultrasonography, we also participate in a regional project examining the regulation of follicle development in cattle.

Faculty Award Winner

Award Type:  COLSA Outstanding Advisor Award
Year:  2013

Courses Taught

  • BCHM/BMS 802/702: Endocrinology
  • BMCB 799H: Honors Senior Thesis
  • INCO 590: Rsrch Exp/MCBS
  • INCO 790: Advanced Research Experience
  • MCBS 997: Seminar
  • MCBS 999: Doctoral Research


  • Ph.D., Biology, Boston University
  • B.A., Anatomy and Physiology, Cornell University

Selected Publications

  • Prohaska, B. K., Tsang, P. C. W., III, D. W. B., Hoffmayer, E. R., Wheeler, C. R., & Sulikowski, J. A. (2018). Effects of delayed phlebotomy on plasma steroid hormone concentrations in two elasmobranch species. JOURNAL OF APPLIED ICHTHYOLOGY, 34(4), 861-866. doi:10.1111/jai.13700

  • Foradori, M. J., Chen, Q., Fernandez, C. A., Harper, J., Li, X., Tsang, P. C. W., . . . Moses, M. A. (2014). Matrilin-1 Is an Inhibitor of Neovascularization. JOURNAL OF BIOLOGICAL CHEMISTRY, 289(20), 14301-14309. doi:10.1074/jbc.M113.529982

  • Bubley, W. J., Sulikowski, J. A., Koester, D. M., & Tsang, P. C. W. (2013). Using a multi-parameter approach to reassess maturity of spiny dogfish, squalus acanthias, following increased fishing pressure in the western north atlantic. Fisheries Research, 147, 202-212. doi:10.1016/j.fishres.2013.06.004

  • Williams, L. J., Campbell, M. D., Tsang, P. C. W., & Sulikowski, J. A. (2013). Using estradiol and progesterone concentrations to assess individual variability in the reproductive cyclicity of captive female little skates, Leucoraja erinacea, from the western Gulf of Maine. Fish Physiology and Biochemistry, 39(5), 1089-1099. doi:10.1007/s10695-012-9766-2

  • Prohaska, B. K., Tsang, P. C. W., Driggers, W. B., Hoffmayer, E. R., Wheeler, C. R., Brown, A. C., & Sulikowski, J. A. (2013). Assessing reproductive status in elasmobranch fishes using steroid hormones extracted from skeletal muscle tissue.. Conserv Physiol, 1(1), cot028. doi:10.1093/conphys/cot028

  • Townson, D. H., Tsang, P. C. W., Butler, W. R., Frajblat, M., Griel, L. C., Johnson, C. J., . . . Pate, J. L. (2002). Relationship of fertility to ovarian follicular waves before breeding in dairy cows. JOURNAL OF ANIMAL SCIENCE, 80(4), 1053-1058. Retrieved from https://www.webofscience.com/

  • Ahmad, N., Beam, S. W., Butler, W. R., Deaver, D. R., Duby, R. T., Elder, D. R., . . . Inskeep, E. K. (1996). Relationship of fertility to patterns of ovarian follicular development and associated hormonal profiles in dairy cows and heifers. JOURNAL OF ANIMAL SCIENCE, 74(8), 1943-1952. Retrieved from https://www.webofscience.com/

  • Relationship of fertility to patterns of ovarian follicular development and associated hormonal profiles in dairy cows and heifers. Cooperative Regional Research Project. (1996). J Anim Sci, 74(8), 1943-1952. doi:10.2527/1996.7481943x

  • Hinshelwood, M. M., Corbin, C. J., Corbin, C. J., Tsang, P. C. W., Tsang, P. C. W., Simpson, E. R., & Simpson, E. R. (1993). Isolation and characterization of a complementary deoxyribonucleic acid insert encoding bovine aromatase cytochrome P450. Endocrinology, 133(5), 1971-1977.

  • CALLARD, I. P., FILETI, L. A., PEREZ, L. E., SORBERA, L. A., GIANNOUKOS, G., KLOSTERMAN, L. L., . . . MCCRACKEN, J. A. (1992). Role of the Corpus Luteum and Progesterone in the Evolution of Vertebrate Viviparity. Integrative and Comparative Biology, 32(2), 264-275. doi:10.1093/icb/32.2.264

  • Most Cited Publications