Louis Tisa

of Microbiology and Genetics
Phone: (603) 862-2442
Office: Molecular, Cellular, & Biomedical Sciences, Rudman Hall Rm 289, Durham, NH 03824


  • Ph.D., Bacteriology, University of Wisconsin
  • M.S., Microbiology, University of Windsor, Ontario
  • B.S., Biology, University of Windsor, Ontario

Research Interests

  • Environmental Biology
  • Exobiology
  • Functional Genomics
  • Genomics
  • Microbes
  • Microbial Degradation
  • Microbial Processes
  • Microbiology
  • Microbiome
  • Molecular Genetics

Courses Taught

  • BMS 503: General Microbiology
  • BMS 504: General Microbiology Lab
  • BMS 790: Undergrad Teaching Experience
  • BMS 799H: Senior Honors Thesis
  • GEN 717/817: Molecular Microbiology
  • GEN 999: Doctoral Research
  • INCO 590: Rsrch Exp/MCBS
  • MCBS 901: Intro to Research in Life Sci
  • MCBS 999: Doctoral Thesis
  • MICR 999: Doctoral Research

Selected Publications

Oshone, R., Ngom, M., Chu, F., Mansour, S., Sy, M. O., Champion, A., & Tisa, L. S. (2017). Genomic, transcriptomic, and proteomic approaches towards understanding the molecular mechanisms of salt tolerance in Frankia strains isolated from Casuarina trees. BMC Genomics, 18(1). doi:10.1186/s12864-017-4056-0

Petersen, L. M., LaCourse, K., Schöner, T. A., Bode, H., & Tisa, L. S. (2017). Inactivation of the Major Hemolysin Gene Influences Expression of the Nonribosomal Peptide Synthetase Gene
in the Insect Pathogen Serratia sp. Strain SCBI. Journal of Bacteriology, 199(21). doi:10.1128/jb.00333-17

Sghaier, H., Hezbri, K., Ghodhbane-Gtari, F., Pujic, P., Sen, A., Daffonchio, D., . . . Gtari, M. (2016). Stone-dwelling actinobacteria Blastococcus saxobsidens, Modestobacter marinus and Geodermatophilus obscurus proteogenomes. The ISME Journal, 10(1), 21-29. doi:10.1038/ismej.2015.108

Chabaud, M., Gherbi, H., Pirolles, E., Vaissayre, V., Fournier, J., Moukouanga, D., . . . Svistoonoff, S. (2016). Chitinase-resistant hydrophilic symbiotic factors secreted by Frankia
activate both Ca2+
spiking and NIN
gene expression in the actinorhizal plant Casuarina glauca. New Phytologist, 209(1), 86-93. doi:10.1111/nph.13732

Hurst, S., Rowedder, H., Michaels, B., Bullock, H., Jackobeck, R., Abebe-Akele, F., . . . Tisa, L. S. (2015). Elucidation of the Photorhabdus temperata Genome and Generation of a Transposon Mutant Library To Identify Motility Mutants Altered in Pathogenesis. Journal of Bacteriology, 197(13), 2201-2216. doi:10.1128/jb.00197-15

Petersen, L. M., & Tisa, L. S. (2014). Molecular Characterization of Protease Activity in Serratia sp. Strain SCBI and Its Importance in Cytotoxicity and Virulence. Journal of Bacteriology, 196(22), 3923-3936. doi:10.1128/jb.01908-14

Furnholm, T. R., & Tisa, L. S. (2014). The ins and outs of metal homeostasis by the root nodule actinobacterium Frankia. BMC Genomics, 15(1), 1092. doi:10.1186/1471-2164-15-1092

Beauchemin, N. J., Furnholm, T., Lavenus, J., Svistoonoff, S., Doumas, P., Bogusz, D., . . . Tisa, L. S. (2012). Casuarina Root Exudates Alter the Physiology, Surface Properties, and Plant Infectivity of Frankia sp. Strain CcI3. Applied and Environmental Microbiology, 78(2), 575-580. doi:10.1128/aem.06183-11

Udwary, D. W., Gontang, E. A., Jones, A. C., Jones, C. S., Schultz, A. W., Winter, J. M., . . . Moore, B. S. (2011). Significant Natural Product Biosynthetic Potential of Actinorhizal Symbionts of the Genus Frankia, as Revealed by Comparative Genomic and Proteomic Analyses. Applied and Environmental Microbiology, 77(11), 3617-3625. doi:10.1128/aem.00038-11

Niemann, J., & Tisa, L. S. (2008). Nitric Oxide and Oxygen Regulate Truncated Hemoglobin Gene Expression in Frankia Strain CcI3. Journal of Bacteriology, 190(23), 7864-7867. doi:10.1128/jb.01100-08

Eighmy, T. T., Spear, J. C. M., Case, J., Mills, M., Newman, K., Kinner, N. E., . . . Gonsoulin, M. E. (2007). Microfracture Surface Geochemistry and Adherent Microbial Population Metabolism in TCE-Contaminated Competent Bedrock. Geomicrobiology Journal, 24(3-4), 307-330. doi:10.1080/01490450701456610

Normand, P., Lapierre, P., Tisa, L. S., Gogarten, J. P., Alloisio, N., Bagnarol, E., . . . Benson, D. R. (n.d.). Genome characteristics of facultatively symbiotic Frankia sp. strains reflect host range and host plant biogeography. Genome Research, 17(1), 7-15. doi:10.1101/gr.5798407

Cissoko, M., Hocher, V., Gherbi, H., Gully, D., Carré-Mlouka, A., Sane, S., . . . Svistoonoff, S. (n.d.). Actinorhizal Signaling Molecules: Frankia Root Hair Deforming Factor Shares Properties With NIN Inducing Factor. Frontiers in Plant Science, 9. doi:10.3389/fpls.2018.01494