Louis Tisa

of Microbiology and Genetics
Phone: (603) 862-2442
Office: Molecular, Cellular, & Biomedical Sciences, Rudman Hall Rm 289, Durham, NH 03824

Courses Taught

  • BMCB 799H: Honors Senior Thesis
  • BMS 799H: Senior Honors Thesis
  • GEN 606: Genetics Lab
  • GEN 717/817: Molecular Microbiology
  • GEN 790: Undergrad Teaching Experience
  • INCO 590: Student Research Experience
  • MCBS 997: Seminar
  • MCBS 999: Doctoral Research


  • Ph.D., Bacteriology, University of Wisconsin
  • M.S., Microbiology, University of Windsor, Ontario
  • B.S., Biology, University of Windsor, Ontario

Research Interests

  • Environmental Biology
  • Exobiology
  • Functional Genomics
  • Genomics
  • Microbes
  • Microbial Degradation
  • Microbial Processes
  • Microbiology
  • Microbiome
  • Molecular Genetics

Selected Publications

  • Ennis, N. J., Dharumaduri, D., Bryce, J. G., & Tisa, L. S. (2021). Metagenome Across a Geochemical Gradient of Indian Stone Ruins Found at Historic Sites in Tamil Nadu, India. MICROBIAL ECOLOGY, 81(2), 385-395. doi:10.1007/s00248-020-01598-3

  • Louati, M., Ennis, N. J., Ghodhbane-Gtari, F., Hezbri, K., Sevigny, J. L., Fahnestock, M. F., . . . Gtari, M. (2020). Elucidating the ecological networks in stone-dwelling microbiomes. ENVIRONMENTAL MICROBIOLOGY, 22(4), 1467-1480. doi:10.1111/1462-2920.14700

  • Davis, I., Sevigny, J., Kleiner, V., Mercurio, K., Pesce, C., Swanson, E., . . . Tisa, L. S. (2020). Draft Genome Sequences of 10 Bacterial Strains Isolated from Root Nodules of Alnus Trees in New Hampshire. MICROBIOLOGY RESOURCE ANNOUNCEMENTS, 9(2). doi:10.1128/MRA.01440-19

  • Diagne, N., Djighaly, P. I., Ngom, M., Pesce, C., Champion, A., Svistoonoff, S., . . . Tisa, L. S. (2020). Advances in Frankia genome studies and molecular aspects of tolerance to environmental stresses. In MOLECULAR ASPECTS OF PLANT BENEFICIAL MICROBES IN AGRICULTURE (pp. 381-389). doi:10.1016/B978-0-12-818469-1.00031-6

  • Pesce, C., Oshone, R., Hurst, S. G., Kleiner, V. A., & Tisa, L. S. (2019). Stable Transformation of the Actinobacteria Frankia spp.. APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 85(15). doi:10.1128/AEM.00957-19

  • Gherbi, H., Hocher, V., Ngom, M., Diagne, N., Fournier, J., Carre-Mlouka, A., . . . Svistoonoff, S. (2019). Molecular Methods for Research on Actinorhiza. In Methods in Rhizosphere Biology Research (pp. 35-59). doi:10.1007/978-981-13-5767-1_4

  • Ghodhbane-Gtari, F., Nouioui, I., Hezbri, K., Lundstedt, E., D'Angelo, T., McNutt, Z., . . . Tisa, L. S. (2019). The plant-growth-promoting actinobacteria of the genus Nocardia induces root nodule formation in Casuarina glauca. ANTONIE VAN LEEUWENHOEK INTERNATIONAL JOURNAL OF GENERAL AND MOLECULAR MICROBIOLOGY, 112(1), 75-90. doi:10.1007/s10482-018-1147-0

  • Cissoko, M., Hocher, V., Gherbi, H., Gully, D., Carre-Mlouka, A., Sane, S., . . . Svistoonoff, S. (2018). Actinorhizal Signaling Molecules: Frankia Root Hair Deforming Factor Shares Properties With NIN Inducing Factor. FRONTIERS IN PLANT SCIENCE, 9. doi:10.3389/fpls.2018.01494

  • Petersen, L. M., LaCourse, K., Schoener, T. A., Bode, H., & Tisa, L. S. (2017). Inactivation of the Major Hemolysin Gene Influences Expression of the Nonribosomal Peptide Synthetase Gene swrA in the Insect Pathogen Serratia sp Strain SCBI. JOURNAL OF BACTERIOLOGY, 199(21). doi:10.1128/JB.00333-17

  • Oshone, R., Ngom, M., Chu, F., Mansour, S., Sy, M. O., Champion, A., & Tisa, L. S. (2017). Genomic, transcriptomic, and proteomic approaches towards understanding the molecular mechanisms of salt tolerance in Frankia strains isolated from Casuarina trees. BMC GENOMICS, 18. doi:10.1186/s12864-017-4056-0

  • Furnholm, T., Rehan, M., Wishart, J., & Tisa, L. S. (2017). Pb2+ tolerance by Frankia sp strain EAN1pec involves surface-binding. MICROBIOLOGY-SGM, 163(4), 472-487. doi:10.1099/mic.0.000439

  • Ngom, M., Gray, K., Diagne, N., Oshone, R., Fardoux, J., Gherbi, H., . . . Champion, A. (2016). Symbiotic Performance of Diverse Frankia Strains on Salt-Stressed Casuarina glauca and Casuarina equisetifolia Plants. FRONTIERS IN PLANT SCIENCE, 7. doi:10.3389/fpls.2016.01331

  • Chabaud, M., Gherbi, H., Pirolles, E., Vaissayre, V., Fournier, J., Moukouanga, D., . . . Svistoonoff, S. (2016). Chitinase-resistant hydrophilic symbiotic factors secreted by Frankia activate both Ca2+ spiking and NIN gene expression in the actinorhizal plant Casuarina glauca. NEW PHYTOLOGIST, 209(1), 86-93. doi:10.1111/nph.13732

  • Sghaier, H., Hezbri, K., Ghodhbane-Gtari, F., Pujic, P., Sen, A., Daffonchio, D., . . . Gtari, M. (2016). Stone-dwelling actinobacteria Blastococcus saxobsidens, Modestobacter marinus and Geodermatophilus obscurus proteogenomes. ISME JOURNAL, 10(1), 21-29. doi:10.1038/ismej.2015.108

  • Hurst, S., Rowedder, H., Michaels, B., Bullock, H., Jackobeck, R., Abebe-Akele, F., . . . Tisa, L. S. (2015). Elucidation of the Photorhabdus temperata Genome and Generation of a Transposon Mutant Library To Identify Motility Mutants Altered in Pathogenesis. JOURNAL OF BACTERIOLOGY, 197(13), 2201-2216. doi:10.1128/JB.00197-15

  • Furnholm, T. R., & Tisa, L. S. (2014). The ins and outs of metal homeostasis by the root nodule actinobacterium Frankia. BMC GENOMICS, 15. doi:10.1186/1471-2164-15-1092

  • Petersen, L. M., & Tisa, L. S. (2014). Molecular Characterization of Protease Activity in Serratia sp Strain SCBI and Its Importance in Cytotoxicity and Virulence. JOURNAL OF BACTERIOLOGY, 196(22), 3923-3936. doi:10.1128/JB.01908-14

  • Normand, P., Benson, D. R., Berry, A. M., & Tisa, L. S. (2014). The Family frankiaceae. In E. Rosenberg, E. F. DeLong, S. Lory, E. Stackebrand, & F. Thompson (Eds.), The Prokaryotes- Actinobacteria (pp. 339-356). Berlin Heidelberg: Springer-Verlag. doi:10.1007/978-3-30138-4_183

  • Beauchemin, N. J., Furnholm, T., Lavenus, J., Svistoonoff, S., Doumas, P., Bogusz, D., . . . Tisa, L. S. (2012). Casuarina Root Exudates Alter the Physiology, Surface Properties, and Plant Infectivity of Frankia sp Strain CcI3. APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 78(2), 575-580. doi:10.1128/AEM.06183-11

  • Udwary, D. W., Gontang, E. A., Jones, A. C., Jones, C. S., Schultz, A. W., Winter, J. M., . . . Moore, B. S. (2011). Significant Natural Product Biosynthetic Potential of Actinorhizal Symbionts of the Genus Frankia, as Revealed by Comparative Genomic and Proteomic Analyses. APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 77(11), 3617-3625. doi:10.1128/AEM.00038-11

  • Niemann, J., & Tisa, L. S. (2008). Nitric Oxide and Oxygen Regulate Truncated Hemoglobin Gene Expression in Frankia Strain CcI3. JOURNAL OF BACTERIOLOGY, 190(23), 7864-7867. doi:10.1128/JB.01100-08

  • Normand, P., Lapierre, P., Tisa, L. S., Gogarten, J. P., Alloisio, N., Bagnarol, E., . . . Benson, D. R. (2007). Genome characteristics of facultatively symbiotic Frankia sp strains reflect host range and host plant biogeography. GENOME RESEARCH, 17(1), 7-15. doi:10.1101/gr.5798407