Arturo Andrade

ASSISTANT PROFESSOR
Office: Biological Sciences, Rudman Hall, Durham, NH 03824
Arturo Andrade

General area of Interest and/or Specialty:

Neurobiology of pain and anxiety, voltage-gated calcium channels, human genetics, comparative transcriptomics, neuropharmacology.
Description of Current Research:

Pain and anxiety are two highly prevalent neurological conditions in humans. Unfortunately, the currently available pharmacological treatments for these conditions have many undesirable side effects. The scarcity of specific treatments with a more favorable side effect profile drives my motivation to investigate the molecular mechanisms underlying pain and anxiety. In particular, I focus on the role of neuronal voltage-gated calcium channels and endocannabinoids in specific cell populations of the pain pathway and in brain areas implicated in anxiety-like behavior. Voltage-gated calcium channels are key players in the modulation of neuronal circuits associated with pain and anxiety. In addition, endocannabinoids are internal signaling molecules that relieve pain and anxiety, partially by inhibiting voltage-gated calcium channels. My goal is to understand the coupling of endocannabinoids to voltage-gated calcium channels in cell-specific neuronal populations during situations that induce anxiety or chronic pain. To achieve this goal, I use modern electrophysiological techniques coupled to optogenetics, unique genetic models, and behavior. In the long term, I am interested in finding new cell-specific targets to mitigate anxiety-like behavior and pain. To do this, I will compare whole-cell transcriptome across specific neuronal subpopulations that are highly linked to anxiety and pain. As part of extensive collaborations with human geneticists, I also study mutations in voltage-gated calcium channels that are linked to neurological disorders, including myoclonus dystonia and schizophrenia.

If you are interested in doing exciting research in an environment that values diversity and the provision of high-quality mentorship, please contact me.

Education

  • Ph.D., National Polytechnic Institute of Toulouse
  • B.S., University of Michoacan

Courses Taught

  • BIOL/NSB 805/705: Neurbiology
  • BMS 795W: Investigations Biomedical Sci
  • BMS 799H: Senior Honors Thesis
  • INCO 590: Rsrch Exp/Biological Sciences
  • INCO 790: Adv Rsrch Exp/Biol Sci
  • NSB 500: Neuroscience and Behavior I
  • NSB 501: Neurobiology Laboratory I
  • NSB 795W: Special Investigations
  • NSB 799H: Honors Senior Thesis

Selected Publications

Bunda, A., LaCarubba, B., Bertolino, M., Akiki, M., Bath, K., Lopez-Soto, J., . . . Andrade, A. (2019). Cacna1b alternative splicing impacts excitatory neurotransmission and is linked to behavioral responses to aversive stimuli.. Mol Brain, 12(1), 81. doi:10.1186/s13041-019-0500-1

Bunda, A., LaCarubba, B., Akiki, M., & Andrade, A. (2019). Tissue- and cell-specific expression of a splice variant in the II-III cytoplasmic loop of Cacna1b.. FEBS Open Bio, 9(9), 1603-1616. doi:10.1002/2211-5463.12701

Andrade, A., Brennecke, A., Mallat, S., Brown, J., Gomez-Rivadeneira, J., Czepiel, N., & Londrigan, L. (2019). Genetic Associations between Voltage-Gated Calcium Channels and Psychiatric Disorders.. Int J Mol Sci, 20(14). doi:10.3390/ijms20143537

Andrade, A., Brennecke, A., Mallat, S., Brown, J., Gomez-Rivadeneira, J., Czepiel, N., & Londrigan, L. (2019). Genetic Associations between Voltage-Gated Calcium Channels and Psychiatric Disorders. doi:10.20944/preprints201906.0192.v1

Sandoval, A., Duran, P., Gandini, M. A., Andrade, A., Almanza, A., Kaja, S., & Felix, R. (2017). Regulation of L-type CaV1.3 channel activity and insulin secretion by the cGMP-PKG signaling pathway.. Cell Calcium, 66, 1-9. doi:10.1016/j.ceca.2017.05.008

Andrade, A., Hope, J., Allen, A., Yorgan, V., Lipscombe, D., & Pan, J. Q. (2016). A rare schizophrenia risk variant of CACNA1I disrupts CaV3.3 channel activity.. Sci Rep, 6, 34233. doi:10.1038/srep34233

Lipscombe, D., Andrade, A., & Allen, S. E. (2013). Alternative splicing: functional diversity among voltage-gated calcium channels and behavioral consequences.. Biochim Biophys Acta, 1828(7), 1522-1529. doi:10.1016/j.bbamem.2012.09.018

Marangoudakis, S., Andrade, A., Helton, T. D., Denome, S., Castiglioni, A. J., & Lipscombe, D. (2012). Differential ubiquitination and proteasome regulation of Ca(V)2.2 N-type channel splice isoforms.. J Neurosci, 32(30), 10365-10369. doi:10.1523/JNEUROSCI.0851-11.2012

Calderón-Rivera, A., Andrade, A., Hernández-Hernández, O., González-Ramírez, R., Sandoval, A., Rivera, M., . . . Felix, R. (2012). Identification of a disulfide bridge essential for structure and function of the voltage-gated Ca(2+) channel α(2)δ-1 auxiliary subunit.. Cell Calcium, 51(1), 22-30. doi:10.1016/j.ceca.2011.10.002

Andrade, A., Sandoval, A., González-Ramírez, R., Lipscombe, D., Campbell, K. P., & Felix, R. (2009). The alpha(2)delta subunit augments functional expression and modifies the pharmacology of Ca(V)1.3 L-type channels.. Cell Calcium, 46(4), 282-292. doi:10.1016/j.ceca.2009.08.006

Most Cited Publications