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Gabriella Angelini

Gabriella Angelini, M.S. Student, Genetics

Gabriella Angelina


Advisor: Dr. Estelle Hraback

Research Topic: Characterizing the role of Protein Phosphotase 2A in root development under salt stress in Arabidopsis thaliana

Protein kinases and phosphatases are a cell’s essential system of regulation within and amongst cells. Kinases add a phosphate group to other proteins whereas phosphatases remove them. Protein phosphatase 2A (PP2A) is made up of three subunits named A, B, and C, each of which is encoded by multiple genes. The focus of this study is the C-subunit, also known as the catalytic subunit, and is the site of dephosphorylation. In Arabidopsis, when PP2A’s C-subunit is mutated it exhibits normal root development when on a vertically oriented agar plate. However, when salt (NaCl) is added to the medium the roots skew to the right, when viewed from the back of the plate. This skewing phenotype, as a result of salt stress, is not seen in wild type seedlings. With this project, I hope to further understand the cause of this phenotype, PP2A’s role in the regulation of development while under stress, and other proteins it is associated with.