Meng Chen, Ph.D.

Meng Chen, Ph.D.

Clinical Assistant Professor

Educational Background:

Ph.D., University of Texas Health Science Center at Houston & MD Anderson Cancer Center, 8/2009
B.S., Nanjing University, Nanjing, China, 7/2003

Clinical rotations:

  • MD Anderson Cancer Center laboratories: Chemistry, Immunology, Toxicology, Hematology and Coagulation, Microbiology, POCT, Specimen Collection and Processing, Molecular Diagnosis, and Quality Control and Management, MD Anderson Regional Campus
  • Houston Methodist Hospital
  • Baylor College of Medicine: Texas Children’s Hospital, Michael E. DeBakey VA Medical Center, Ben Taub Hospital, Baylor St. Luke's Medical Center

Courses:

  •   BMS 610 - Laboratory Management
  •   BMS 658 - Medical Biochemistry
  •   BMS 659 - Medical Biochemistry Laboratory

General Area of Interest and/or Specialty:

Clinical chemistry, laboratory management, laboratory medicine, cancer genetics, molecular epidemiology

Honors

Fellowships:

  • Clinical Chemistry Fellowship, the Commission on Accreditation in Clinical Chemistry (Comacc) Accredited Fellowship Training Program, The University of Texas MD Anderson Cancer Center, 7/2013-7/2015
  • Duncan Family Institute Mentored Junior Faculty Fellowship, The University of Texas MD Anderson Cancer Center, 4/2012-7/2013
  • CPRIT Postdoctoral Fellowship, Cancer Prevention and Research Institute of Texas (CPRIT) Innovation Training Grant, Houston, TX, 12/2010−10/2012

Awards:

  • Patient Safety Abstract Award, Management Sciences and Patient Safety Leadership Seminar, American Association for Clinical Chemistry, 2014
  • Society for Young Clinical Laboratorians (SYCL) Travel Grant, American Association for Clinical Chemistry, 2014
  • AACR-Aflac, Incorporated Scholar-in-Training Award, American Association for Cancer Research, 2012
  • Travel Award, 12th International Meeting on Human Genome Variation and Complex Genome Analysis, 2011
  • John Quale Travel Award, Bladder Cancer Advocacy Network (BCAN), 2011
  • Merck Scholar-in-Training Award, American Association for Cancer Research (AACR), 2010
  • 1st Place in Poster Presentation, “Personalized Cancer Therapy and Prevention,” at Symposia on Cancer Research, The University of Texas MD Anderson Cancer Center, 2010
  • Poster Finalist of Graduate Student Award in Translational Research, The University of Texas MD Anderson Cancer Center, 2009
  • Bristol-Myers Squibb Scholar-in-Training Award, American Association for Cancer Research (AACR), 2009
  • Susan G Komen for the Cure Scholar-in-Training Award, American Association for Cancer Research (AACR), 2008
  • Poster Finalist of Graduate Student Award in Basic Science Research, The University of Texas MD Anderson Cancer Center, 2008
  • Renmin Scholarship for Academic Excellence, Nanjing University, 2001−2002, 2002−2003
  • Excellence Student Award for Academic Achievement, Nanjing University, 2001−2002

Publications:

Xing J, Zhu Y, Zhao H, Yang H, Chen M, Spitz MR, Wu X. Differential induction in telomerase activity among bladder cancer patients and controls on gamma-radiation. Cancer Epidemiol Biomarkers Prev 16(3):606-9, 3/2007. 

Chen M, Gu J, Xing J, Spitz MR, Wu X. Irradiation-induced telomerase activity and the risk of lung cancer: a pilot case-control study. Cancer 109(6):1157-63, 3/2007. 

Chen M, Kamat AM, Huang M, Grossman HB, Dinney CP, Lerner SP, Wu X, Gu J. High-order interactions among genetic polymorphisms in nucleotide excision repair pathway genes and smoking in modulating bladder cancer risk. Carcinogenesis 28(10):2160-5, 10/2007. e-Pub 8/2007.

Xing J, Chen M, Wood CG, Lin J, Spitz MR, Ma J, Amos CI, Shields PG, Benowitz NL, Gu J, de Andrade M, Swan GE, Wu X. Mitochondrial DNA content: its genetic heritability and association with renal cell carcinoma. J Natl Cancer Inst 100(15):1104-12, 8/2008. e-Pub 7/2008. PMCID: PMC2720693.

Gu J, Horikawa Y, Chen M, Dinney CP, Wu X. Benzo(a)pyrene diol epoxide-induced chromosome 9p21 aberrations are associated with increased risk of bladder cancer. Cancer Epidemiol Biomarkers Prev 17(9):2445-50, 9/2008.

Ye Y, Lippman SM, Lee JJ, Chen M, Frazier ML, Spitz MR, Wu X. Genetic variations in cell-cycle pathway and the risk of oral premalignant lesions. Cancer 113(9):2488-95, 11/2008. PMCID: PMC2577230.

Li S, Li J, Cheng J, Zhou B, Tong X, Dong X, Wang Z, Hu Q, Chen M, Hua ZC. Non-syndromic tooth agenesis in two Chinese families associated with novel missense mutations in the TNF domain of EDA (ectodysplasin A). PLoS One 3(6):e2396, 2008. e-Pub 6/2008. PMCID: PMC2405930.

Xing J, Ajani JA, Chen M, Izzo J, Lin J, Chen Z, Gu J, Wu X. Constitutive short telomere length of chromosome 17p and 12q but not 11q and 2p is associated with an increased risk for esophageal cancer. Cancer Prev Res (Phila) 2(5):459-65, 5/2009. e-Pub 4/2009. PMCID: PMC2701666.

Lin J, Kamat A, Gu J, Chen M, Dinney CP, Forman MR, Wu X. Dietary intake of vegetables and fruits and the modification effects of GSTM1 and NAT2 genotypes on bladder cancer risk. Cancer Epidemiol Biomarkers Prev 18(7):2090-7, 7/2009. e-Pub 6/2009.

Chen M, Ye Y, Yang H, Tamboli P, Matin S, Tannir NM, Wood CG, Gu J, Wu X. Genome-wide profiling of chromosomal alterations in renal cell carcinoma using high-density single nucleotide polymorphism arrays. Int J Cancer 125(10):2342-8, 11/2009. PMCID: PMC2768265.

Chen M, Cassidy A, Gu J, Delclos GL, Zhen F, Yang H, Hildebrandt MA, Lin J, Ye Y, Chamberlain RM, Dinney CP, Wu X. Genetic variations in PI3K-AKT-mTOR pathway and bladder cancer risk. Carcinogenesis 30(12):2047-52, 2009. e-Pub. PMCID: PMC2792319.

Chen M, Gu J, Delclos GL, Killary AM, Fan Z, Hildebrandt MA, Chamberlain RM, Grossman HB, Dinney CP, Wu X. Genetic variations of the PI3K-AKT-mTOR pathway and clinical outcome in muscle invasive and metastatic bladder cancer patients. Carcinogenesis 31(8):1387-91, 8/2010. e-Pub 6/2010. PMCID: PMC2915631.

Chen M, Hildebrandt MA, Clague J, Kamat AM, Picornell A, Chang J, Zhang X, Izzo J, Yang H, Lin J, Gu J, Chanock S, Kogevinas M, Rothman N, Silverman DT, Garcia-Closas M, Grossman HB, Dinney CP, Malats N, Wu X. Genetic variations in the sonic hedgehog pathway affect clinical outcomes in non-muscle-invasive bladder cancer. Cancer Prev Res (Phila) 3(10):1235-45, 10/2010. e-Pub 9/2010. PMCID: PMC2955764.

Rothman N, Garcia-Closas M, Chatterjee N, Malats N, Wu X, Figueroa JD, Real FX, Van Den Berg D, Matullo G, Baris D, Thun M, Kiemeney LA, Vineis P, De Vivo I, Albanes D, Purdue MP, Rafnar T, Hildebrandt MA, Kiltie AE, Cussenot O, Golka K, Kumar R, Taylor JA, Mayordomo JI, Jacobs KB, Kogevinas M, Hutchinson A, Wang Z, Fu YP, Prokunina-Olsson L, Burdett L, Yeager M, Wheeler W, Tardón A, Serra C, Carrato A, García-Closas R, Lloreta J, Johnson A, Schwenn M, Karagas MR, Schned A, Andriole G, Grubb R, Black A, Jacobs EJ, Diver WR, Gapstur SM, Weinstein SJ, Virtamo J, Cortessis VK, Gago-Dominguez M, Pike MC, Stern MC, Yuan JM, Hunter DJ, McGrath M, Dinney CP, Czerniak B, Chen M, Yang H, Vermeulen SH, Aben KK, Witjes JA, Makkinje RR, Sulem P, Besenbacher S, Stefansson K, Riboli E, Brennan P, Panico S, Navarro C, Allen NE, Bueno-de-Mesquita HB, Trichopoulos D, Caporaso N, Landi MT, Canzian F, Ljungberg B, Tjonneland A, Clavel-Chapelon F, Bishop DT, Teo MT, Knowles MA, Guarrera S, Polidoro S, Ricceri F, Sacerdote C, Allione A, Cancel-Tassin G, Selinski S, Hengstler JG, Dietrich H, Fletcher T, Rudnai P, Gurzau E, Koppova K, Bolick SC, Godfrey A, Xu Z, Sanz-Velez JI, D García-Prats M, Sanchez M, Valdivia G, Porru S, Benhamou S, Hoover RN, Fraumeni JF, Silverman DT, Chanock SJ. A multi-stage genome-wide association study of bladder cancer identifies multiple susceptibility loci. Nat Genet 42(11):978-84, 11/2010. e-Pub 10/2010. PMCID: PMC3049891.

Gu J, Chen M (co-first author), Shete S, Amos CI, Kamat A, Ye Y, Lin J, Dinney CP, Wu X. A genome-wide association study identifies a locus on chromosome 14q21 as a predictor of leukocyte telomere length and as a marker of susceptibility for bladder cancer. Cancer Prev Res (Phila) 4(4):514-21, 4/2011. e-Pub 4/2011. PMCID: PMC3076128.

Lin J, Forman MR, Wang J, Grossman HB, Chen M, Dinney CP, Hawk ET, Wu X. Intake of red meat and heterocyclic amines, metabolic pathway genes and bladder cancer risk. Int J Cancer 131(8):1892-903, 10/2012. e-Pub 3/2012. PMCID: PMC3415602.

Wei H, Kamat A, Chen M, Ke HL, Chang DW, Yin J, Grossman HB, Dinney CP, Wu X. Association of polymorphisms in oxidative stress genes with clinical outcomes for bladder cancer treated with Bacillus Calmette-Guérin. PLoS One 7(6):e38533, 2012. e-Pub 6/2012. PMCID: PMC3373532.

Ke H, Chen M, Ye Y, Hildebrandt M, Wu W, Wei H, Huang M, Chang DW, Dinney CP, Wu X. Genetic variations in microRNA-biogenesis genes as predictors of recurrence and progression for non-muscle invasive bladder cancer patients. Carcinogenesis. 34(5):1006-11, 5/2013. PMCID: PMC3643413

Sanchez-Espiridion B, Chen M, Chang JY, Lu C, Chang DW, Roth JA, Wu X, Gu J. Telomere length in peripheral blood leukocytes and lung cancer risk: a large case-control study in Caucasians. Cancer Research, 74(9): 2476-86, 5/2014. PMID: 24618342

Chen M, Calin G, Meng Q. Circulating microRNA as promising tumor biomarkers. Advances in Clinical Chemistry, volume 67: 189-214, 11/2014. doi:10.1016/bs.acc.2014.09.007

Lin J, Blalock J, Chen M, Cohen L, Cinciripini P, Wu X. Depressive symptoms and short telomere length increased mortality in bladder cancer patients.  Cancer Epidemiology, Biomarkers & Prevention, 24(2):336-43, 2/2015. doi: 10.1158/1055-9965.EPI-14-0992. Epub 2014 Nov 21.

Chen M, Meng Q, Chapter 30: Chemotherapy drug monitoring by liquid chromatography-tandem mass spectrometry. Applications of Liquid Chromatography-Mass Spectrometry in Clinical Laboratories. Shanghai Scientific & Technical Publishers, 10/2014. ISBN 978-7-5478-2373-6

Miao C, Chen M, Wang Z, Wang T. Microcystin-LR promotes migration and invasion of colorectal cancer cells via of Matrix Metalloproteinase-13 activation. Molecular Carcinogenesis, 2015, In Press

Chen M, Meng Q, Recurrent hyperkalemia in a patient with chronic lymphocytic leukemia. American Society for Clinical Pathology (ASCP) Case Reports, 2015, In Press.

Shu X, Purdue MP, Ye Y, Wood CG, Chen M, Wang Z, Albanes D, Pu X, Huang M, Stevens VL, Diver WR, Gapstur SM, Virtamo J, Chow W, Tannir NT, Dinney CP, Rothman N, Chanock SJ, Wu X. Multilevel-analysis identify a cis-expression quantitative trait locus associated with risk of renal cell carcinoma. Oncotarget, 2/2015, PMID 25784652.

Chen M, Rothman N, Ye Y, Gu J, Scheet P, Huang M, Chang D, Dinney C, Chanock SJ, Wu X. Pathway analysis of bladder cancer genome-wide association study identifies novel pathways involved in bladder cancer development, Oncotarget, Submitted

Tan W, Chen M, Ye Y, Hildebrandt M, Huang M, Chang DW, Wu X. Association of genetic variants in the sonic hedgehog pathway genes with ovarian cancer risk. Clinical Genetics, Submitted 

Ren Y, Chen M, Zhu Q, Zhou L, Wei Q, Wang T. Microcystin-LR promotes epithelial-mesenchymal transition in colorectal cancer through Smad2 activation. Toxicology, Submitted

Invited Talks and Posters:

Chen M,  Ajani JA, Shao L, Lin J, Huang M, Hittelman WN, Wu X. Cell cycle checkpoints, DNA damage/repair, and risk of esophageal cancer. International Society of Gastrointestinal Oncology, 9/2006. 

Chen M, Gu J, Huang M, Grossman HB, Dinney CP, Xifeng Wu X. High-order interactions among genetic polymorphisms in nucleotide excision repair pathway genes and smoking in modulating bladder cancer risk. The 98th Annual Meeting of the American Association for Cancer Research (AACR), 4/2007.

Xing J, Ajani JA, Chen M, Yang H, Izzo J, Wu X. Association of constitutional short overall and chromosome specific telomere length with increased esophageal cancer risk: a paired case-control analysis. The 98th Annual Meeting of the American Association for Cancer Research, 4/ 2007.

Xing J, Ajani JA, Chen M, Izzo J, Wu X. Constitutive short chromosome-specific telomere length of 17p and 12q, but not XpYp, 11q and 2p is associated with increased esophageal cancer risk. The Second AACR International Conference on Molecular Diagnostics in Cancer Therapeutic Development, 9/2007. 

Chen M, Ye Y, Yang H, Matin S, Tannir NM, Wood CG, Gu J, Wu X. Genome-wide profiling of chromosomal alterations in renal cell carcinoma using high-density single nucleotide polymorphism arrays. The 99th Annual Meeting of the American Association for Cancer Research, 4/2008. 

Chen M, Cassidy A, Gu J, Yang H, Lin J, Ye Y, Hildebrant M, Dinney CP, Wu X. Genetic variations in PI3K-AKT-mTOR pathway and bladder cancer risk. The 7th Annual AACR International Conference on Frontiers in Cancer Prevention Research, 11/2008.\

Chen M, Gu J, Grossman HB, Lin J, Huang M, Ye Y, Dinney CP, Wu X. Genetic variations in PI3K-AKT-mTOR pathway and bladder cancer clinical outcome. The 100th Annual Meeting of the American Association for Cancer Research, 4/2009. (Talk) 

Chen M, Genetic variations in PI3K-AKT-mTOR pathway and bladder cancer susceptibility and clinical outcomes, The GU (Bladder) SPORE Seminar, The University of Texas MD Anderson Cancer Center, Epidemiology, Houston, TX, 8/2009. (Talk) 

Chen M, Kamat A, Hildebrandt M, Zhang X, Grossman HB, Dinney CP, Wu X. Genetic variations in the sonic hedgehog pathway and clinical outcomes in bladder cancer. The 8th Annual AACR International Conference on Frontiers in Cancer Prevention Research, 12/2009. (Talk)

Chen M, Lerner S, McConkey D, Gu J, Lin J, Kamat A, Grossman HB, Dinney CP, Wu X. Genetic variation in the Angiogenesis pathway and bladder cancer clinical outcomes. The 101st Annual Meeting of the American Association for Cancer Research, 4/2010.

Lin J, Wang J, Grossman HB, Chen M, Dinney CP, Wu X. Red meat and heterocyclic amine intake, metabolic pathway genes, and bladder cancer risk. The 101st Annual Meeting of the American Association for Cancer Research, 4/2010.

Chen M, Hildebrandt M, Clague J, Kamat AM, Picornell A, Zhang X, Izzo J, Yang H, Lin J, Gu J, Chanock S, Kogevinas M, Rothman N, Silverman DT, Garcia-Closas M, Grossman HB, Dinney CP, Malats N, Wu X. Genetic variations in the sonic hedgehog pathway affect clinical outcomes in non-muscle-invasive bladder cancer. Symposia on Cancer Research “Personalized Cancer Therapy and Prevention”, 10/ 2010. 

Chen M, Hildebrandt M, Clague J, Kamat AM, Picornell A, Zhang X, Izzo J, Yang H, Lin J, Gu J, Chanock S, Kogevinas M, Rothman N, Silverman DT, Garcia-Closas M, Grossman HB, Dinney CP, Malats N, Wu X. Genetic variations in the sonic hedgehog pathway affect clinical outcomes in bladder cancer. Innovations in Cancer Prevention and Research Conference, 11/ 2010.

Chen M, Pathway based analysis of clinical outcomes, International Consortium of Bladder Cancer, Houston, TX, 12/2010 (Talk)

Chen M, Gu J, Ye Y, Lin J, Chang D, Wu X. Genetic determinants of telomere length-A genome wide association study. The 102nd Annual Meeting of the American Association for Cancer Research, 4/2011.

Wei H, Kamat A, Gu J, Chen M, Lin J, Grossman HB, Dinney CP, Shete S, Wu X. Oxidative stress genes polymorphisms are associated with clinical outcomes in bladder cancer patients. The 102nd Annual Meeting of the American Association for Cancer Research, 4/2011.

Ke H, Chen M, Dinney CP, Wu X. Genetic variations in microRNA-related genes as predictors for recurrence and progression in patients with non-muscle invasive bladder cancer. The 102nd Annual Meeting of the American Association for Cancer Research, 4/2011.

Chen M, Gu J, Shete S, Amos CI, Kamat A, Ye Y, Lin J, Dinney CP, Wu X. A Genome-wide association study identifies a locus on chromosome 14q21 as a predictor of leukocyte telomere length and as a marker of susceptibility for bladder cancer. Society of Chinese Bioscientists in America (SCBA) Texas Chapter Annual Symposium, 4/2011. (Talk)

Chen M, Gu J, Shete S, Amos CI, Kamat A, Ye Y, Lin J, Dinney CP, Wu X. A Genome-wide association study identifies a locus on chromosome 14q21 as a predictor of leukocyte telomere length and as a marker of susceptibility for bladder cancer. Bladder Cancer Think Tank, 8/2011. (Talk)

Chen M, Gu J, Shete S, Amos CI, Kamat A, Ye Y, Lin J, Dinney CP, Wu X. A genome-wide association study identifies a locus on chromosome 14q21 as a predictor of leukocyte telomere length and as a marker of susceptibility for bladder cancer. The12th International Meeting on Human Genome Variation and Complex Genome Analysis, 9/2011.

Chen M, Identification of pathway associated with bladder cancer risk using gene set enrichment analysis, MD Anderson Cancer Center, Department of Epidemiology, Houston, TX, 3/2012  (Talk)

Chen M, Ye Y, Dinney CP, Wu X. Gene set enrichment analysis of bladder cancer genome-wide association study identifies several novel pathways involved in bladder cancer development. The 103rd Annual Meeting of the American Association for Cancer Research, 4/2012.

Chen M, Ye Y, Dinney CP, Wu X. Pathway analysis of bladder cancer genome-wide association study identifies several novel pathways involved in bladder cancer development. Innovations in Cancer Prevention and Research Conference, 10/2012. (Talk)

Chen M, Lin J, Blalock J, Cohen L, Cinciripini PM, Wu X. Depression and short telomere length increased mortality in bladder cancer patients. The 11th Annual AACR International Conference on Frontiers in Cancer Prevention Research, 10/2012.

Shu X, Chen M, Ye Y, Huang M, Gu J, Wood CG, Wu X. Gene set enrichment analysis of renal cell carcinoma genome-wide association data identifies the JAK-STAT pathway mediating susceptibility. The 11th Annual AACR International Conference on Frontiers in Cancer Prevention Research, 10/2012.

Chen M, Gu J, Gong Y, Ajani J, Wu X. Short overall telomere length and chromosome 17p-specific telomere length in peripheral blood leukocytes are associated with increased risk of esophageal adenocarcinoma. The 104th Annual Meeting of the American Association for Cancer Research, 4/2013.

Genotype and intermediate biomarker for cancer risk and outcome, MD Anderson Cancer Center, Department of Laboratory Medicine, Houston, TX, 5/2013  (Talk)

Chen M, Handy BC, Wagar EA, Meng Q. Laboratory investigation of spurious hyperkalemia. 2014 American Association for Clinical Chemistry Annual Meeting, 7/2014

Chen M, Handy BC, Wagar EA, Meng Q. Factual or fictitious hypocalcemia? 2014 American Association for Clinical Chemistry Annual Meeting, 7/2014

Chen M, Handy BC, Wagar EA, Meng Q. Investigation on causes and impact of specimen rejection in clinical chemistry laboratory. 2014 American Association for Clinical Chemistry Annual Meeting, 7/2014

Vejpongsa P, Chen M, Araujo DM, Massey MR, Banchs J, Acholonu SA, Hassan SA, Meng Q, Yeh ETH. Comparing the efficacy of primary prevention strategies in Doxorubicin-induced cardiotoxicity using Echocardiography and High-Sensitivity Troponin T. Scientific Sessions of American Heart Association. 12/2014

Update on Cardiac Markers: Focus on Troponins in ACS. Citywide Clinical Pathology Grand Rounds. Baylor College of Medicine & Houston Methodist Hospital. 7/2015 (Talk)

Professional Memberships:

  • American Association for Cancer Research, Since 2006
  • International Society of Gastrointestinal Oncology, Since 2006
  • Bladder Cancer Advocacy Network, Since 2011
  • American Association for Clinical Chemistry, Since 2013
Meng Chen
Kendall Hall, Room 217
Durham, NH 03824
Phone: 
(603) 862-0715