Arturo Andrade, Ph.D.

Arturo Andrade, Ph.D.

Assistant Professor, Neurobiology

Educational Background:

  • Post-Doctoral Research Associate, Brown University, 2015
  • Ph.D. in Cellular and Molecular Neurobiology, Cinvestav-IPN, 2008
  • B. Sc. in Chemistry, Pharmacology and Biology, University of Michoacan, 2002

Courses:

  • NSB 500 Cellular and Molecular Neuroscience and Behavior
  • NSB 502 Cellular and Molecular Neuroscience and Behavior Lab

General area of Interest and/or Specialty:

Neurobiology of pain and anxiety, voltage-gated calcium channels, human genetics, comparative transcriptomics, neuropharmacology.

Description of Current Research:

Pain and anxiety are two highly prevalent neurological conditions in humans. Unfortunately, the currently available pharmacological treatments for these conditions have many undesirable side effects. The scarcity of specific treatments with a more favorable side effect profile drives my motivation to investigate the molecular mechanisms underlying pain and anxiety. In particular, I focus on the role of neuronal voltage-gated calcium channels and endocannabinoids in specific cell populations of the pain pathway and in brain areas implicated in anxiety-like behavior. Voltage-gated calcium channels are key players in the modulation of neuronal circuits associated with pain and anxiety. In addition, endocannabinoids are internal signaling molecules that relieve pain and anxiety, partially by inhibiting voltage-gated calcium channels. My goal is to understand the coupling of endocannabinoids to voltage-gated calcium channels in cell-specific neuronal populations during situations that induce anxiety or chronic pain. To achieve this goal, I use modern electrophysiological techniques coupled to optogenetics, unique genetic models, and behavior. In the long term, I am interested in finding new cell-specific targets to mitigate anxiety-like behavior and pain. To do this, I will compare whole-cell transcriptome across specific neuronal subpopulations that are highly linked to anxiety and pain. As part of extensive collaborations with human geneticists, I also study mutations in voltage-gated calcium channels that are linked to neurological disorders, including myoclonus dystonia and schizophrenia.

If you are interested in doing exciting research in an environment that values diversity and the provision of high-quality mentorship, please contact me.

Selected Publications:

Lipscombe D, Andrade A (2015) Calcium channel CaVa1 splice isoforms – Tissue specificity and drug action. Curr Mol Pharmacol.

Andrade* A, Groen* JL, , Ritz K, Jalalzadeh H, Haagmans M, Bradley TE, Jongejan A, Verbeek DS, Nürnberg P, Denome S, Hennekam RC, Lipscombe* D, Baas* F, Tijssen* MA (2014) CACNA1B mutation is linked to unique myoclonus-dystonia syndrome. Hum Mol Genet.

Andrade* A, Jiang* Yi-Qiu, Lipscombe D (2013). Spinal morphine but not ziconotide or gabapentin analgesia is affected by alternative splicing of voltage-gated calcium channel CaV2.2 pre-mRNA. Mol Pain.

Lipscombe D, Andrade A, Allen SE. (2013) Alternative splicing: functional diversity among voltage-gated calcium channels and behavioral consequences. Biochim Biophys Acta.

Marangoudakis S, Andrade A, Helton TD, Denome S, Castiglioni AJ, Lipscombe D.  (2012) Differential ubiquitination and proteasome regulation of CaV2.2 N-type channel splice isoforms. J Neurosci.

Andrade* A, Denome* S, Jiang Y, Marangoudakis S, Lipscombe D. (2010) Opioid inhibition of N-type Ca2

Arturo Arturo
210 Rudman Hall
Phone: 
(603)862-0015